When two fathers on opposite sides of the country are murdered at the exact same time in the exact same way, Mulder and Scully are called in to investigate.
Mulder and Scully travel to an American Indian reservation to investigate the death of an Indian man who was mistaken for a wild animal and may have been the legendary Manitou, a man who can shapeshift into a beast.
When a group of loggers in the Washington State National Forest disappear in the same way that another group disappeared 50 years ago, Mulder and Scully go along to investigate.
Eugene Tooms, the genetic mutant, is released from the sanitarium and Mulder becomes personally involved to ensure that he is caught in the act of getting the last human liver he needs to go into hibernation for another 30 years.