Umbrella, the most powerful comercial entity in the world. 9/10 homes carry its products. But, even unknown to its employees, Umbrella is known for the development of new viral weaponry. The Tyrant Virus, অথবা T-Virus is the newest most powerful.

Kate and Humphrey, two of Raccoon City's best S.T.A.R.S. agents are sent to investigate the mysterious disappearances of former member Albert Wesker. Accompanied দ্বারা Garth and Lilly, two rookies, they encounter the HIVE, Umbrella's শীর্ষ secret bio-weapon lab. But while the investigation continues, a deadly bio-weapon virus escapes and causes infection throughout the city. Will they get out alive? অথবা will they be infected.